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| Single-Season Shutouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Shutouts | IP | Year | Career Leaderboard |
| 1. | Mark Prior * | 8 | 279.3 | 2009 | |
| 2. | Roger Heitman | 7 | 249.0 | 2013 | |
| Roger Heitman | 7 | 266.3 | 2012 | ||
| 4. | Roy Halladay | 6 | 240.7 | 2008 | |
| 5. | Lewis Washburn | 5 | 239.0 | 2021 | |
| David Martinez | 5 | 261.3 | 2020 | ||
| Freddie Cooley | 5 | 263.3 | 2013 | ||
| Roy Halladay | 5 | 268.7 | 2010 | ||
| Larry Strope | 5 | 261.0 | 2009 | ||
| 10. | Korey Mathison | 4 | 290.7 | 2021 | |
| Silvio Santacruz | 4 | 241.0 | 2021 | ||
| Joseph Koepke | 4 | 225.3 | 2021 | ||
| Byron Abella | 4 | 223.0 | 2021 | ||
| James People | 4 | 213.0 | 2021 | ||
| Bennie Hamblin | 4 | 240.7 | 2020 | ||
| Felipe Granados | 4 | 263.7 | 2019 | ||
| Korey Mathison | 4 | 261.7 | 2019 | ||
| Amadis Rodriguez | 4 | 252.3 | 2019 | ||
| Anthony Lezama | 4 | 244.3 | 2018 | ||
| Lewis Washburn | 4 | 243.0 | 2018 | ||
| Condel Ortiz | 4 | 257.3 | 2017 | ||
| J.D. Martin | 4 | 212.7 | 2013 | ||
| Darren Nigro | 4 | 239.7 | 2012 | ||
| Mark Prior * | 4 | 244.3 | 2011 | ||
| Jeremy Bonderman | 4 | 246.0 | 2009 | ||
| Matt Morris | 4 | 231.7 | 2008 | ||
| Barry Zito | 4 | 236.0 | 2007 | ||
| Bartolo Colon | 4 | 224.7 | 2006 | ||
| Jason Schmidt | 4 | 261.3 | 2005 | ||
| Mark Buehrle | 4 | 259.0 | 2005 | ||
| 31. | Korey Mathison | 3 | 287.3 | 2022 | |
| Brian Anderson | 3 | 239.0 | 2022 | ||
| Joseph Koepke | 3 | 224.3 | 2022 | ||
| Augustine Stearn | 3 | 248.3 | 2021 | ||
| Eric Losey | 3 | 245.7 | 2021 | ||
| Dennis Baley | 3 | 240.7 | 2021 | ||
| Henry Mosqueda | 3 | 225.7 | 2021 | ||
| Steven Hildebrant | 3 | 225.3 | 2021 | ||
| Harry Gioia | 3 | 222.3 | 2021 | ||
| Jeremy Ronquillo | 3 | 220.0 | 2021 | ||
| Brian Anderson | 3 | 263.7 | 2020 | ||
| Zachery Hickman | 3 | 230.3 | 2020 | ||
| Brian Anderson | 3 | 285.3 | 2019 | ||
| David Martinez | 3 | 265.0 | 2019 | ||
| Silvio Santacruz | 3 | 255.0 | 2019 | ||
| Willie Leon | 3 | 237.3 | 2019 | ||
| David Martinez | 3 | 253.3 | 2018 | ||
| Bennie Hamblin | 3 | 234.3 | 2018 | ||
| Korey Mathison | 3 | 231.0 | 2018 | ||
| Brian Anderson | 3 | 185.7 | 2018 | ||
| Daniel Scott | 3 | 168.3 | 2018 | ||
| Augustine Stearn | 3 | 250.3 | 2017 | ||
| John Moore | 3 | 247.7 | 2017 | ||
| Jospeh Chesney | 3 | 198.7 | 2017 | ||
| Roger Heitman | 3 | 170.7 | 2017 | ||
| Julian Abeyta | 3 | 201.7 | 2016 | ||
| Darren Nigro | 3 | 198.0 | 2016 | ||
| Mark Mulder | 3 | 268.3 | 2015 | ||
| Roy Halladay | 3 | 243.0 | 2015 | ||
| Daniel Scott | 3 | 243.0 | 2015 | ||
| Jake Dittler | 3 | 241.0 | 2015 | ||
| Roger Heitman | 3 | 210.7 | 2015 | ||
| Condel Ortiz | 3 | 252.3 | 2014 | ||
| Dave Cedeno | 3 | 241.3 | 2013 | ||
| Roy Halladay | 3 | 241.0 | 2013 | ||
| Nick Younker | 3 | 226.0 | 2012 | ||
| Carlos Zambrano | 3 | 213.7 | 2012 | ||
| Roy Halladay | 3 | 264.7 | 2011 | ||
| Nicholas Lehr | 3 | 230.3 | 2011 | ||
| Roy Halladay | 3 | 275.0 | 2009 | ||
| Tomo Ohka | 3 | 270.0 | 2009 | ||
| Pedro Barranco | 3 | 258.7 | 2009 | ||
| Carlos Zambrano | 3 | 254.0 | 2009 | ||
| Erik Thompson | 3 | 230.3 | 2009 | ||
| Francis Beltran | 3 | 211.7 | 2009 | ||
| Bubba Nelson | 3 | 202.0 | 2009 | ||
| Larry Strope | 3 | 224.0 | 2007 | ||
| Runelvys Hernandez | 3 | 220.7 | 2007 | ||
| Roy Halladay | 3 | 298.3 | 2005 | ||
| Barry Zito | 3 | 236.7 | 2005 | ||
| Randy Johnson | 3 | 254.0 | 2004 | ||
| Mark Mulder | 3 | 239.3 | 2004 | ||
| Josh Beckett | 3 | 228.3 | 2004 | ||
| 84. | David Martinez | 2 | 274.7 | 2022 | |
| Zachery Hickman | 2 | 245.0 | 2022 | ||
| Felipe Granados | 2 | 227.7 | 2022 | ||
| Robert Claxton | 2 | 225.0 | 2022 | ||
| Alex Peņa | 2 | 217.3 | 2022 | ||
| Bill Lazo | 2 | 205.0 | 2022 | ||
| Herbert Bednarz | 2 | 200.7 | 2022 | ||
| Brian Tiger | 2 | 191.7 | 2022 | ||
| Benji Crespo | 2 | 173.7 | 2022 | ||
| Patrick Lynch | 2 | 164.3 | 2022 | ||
| Valeriano Sainz | 2 | 139.0 | 2022 | ||
| Harold Hux | 2 | 138.3 | 2022 | ||
| Richard Eye | 2 | 81.0 | 2022 | ||
| Brian Anderson | 2 | 252.0 | 2021 | ||
| James McEwen | 2 | 231.0 | 2021 | ||
| Martin Straub | 2 | 231.0 | 2021 | ||
| Willie Leon | 2 | 228.7 | 2021 |
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