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| Single-Season Games Pitched Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Games Pitched | IP | Year | Career Leaderboard |
| 1. | Mark Corey | 120 | 137.3 | 2005 | |
| 2. | Scott Linebrink | 117 | 121.7 | 2007 | |
| 3. | Tyler Clippard | 113 | 119.7 | 2013 | |
| Brad Lidge | 113 | 100.3 | 2008 | ||
| 5. | Mark Corey | 112 | 123.3 | 2006 | |
| Matt Mantei | 112 | 99.7 | 2006 | ||
| 7. | Travis Driskill | 111 | 106.0 | 2007 | |
| Bruce Chen | 111 | 125.3 | 2006 | ||
| 9. | Robert Bastarache | 110 | 117.0 | 2018 | |
| Travis Driskill | 110 | 123.3 | 2006 | ||
| Mike Koplove | 110 | 111.7 | 2005 | ||
| Jay Witasick | 110 | 116.3 | 2004 | ||
| 13. | Bruce Chen | 109 | 109.3 | 2007 | |
| Ray King | 109 | 98.0 | 2006 | ||
| 15. | Everett Cortese | 108 | 110.3 | 2016 | |
| Billy Sadler | 108 | 126.3 | 2008 | ||
| John Riedling | 108 | 119.7 | 2006 | ||
| Tim Spooneybarger | 108 | 102.3 | 2005 | ||
| Matt Mantei | 108 | 101.0 | 2005 | ||
| 20. | Adrian Labarbera | 107 | 107.7 | 2012 | |
| Esteban Yan | 107 | 105.0 | 2006 | ||
| Oscar Villarreal | 107 | 104.3 | 2005 | ||
| 23. | Jose Perez | 106 | 132.3 | 2018 | |
| Joselo Diaz | 106 | 105.7 | 2010 | ||
| Ray King | 106 | 110.7 | 2005 | ||
| Mike Koplove | 106 | 116.3 | 2004 | ||
| 27. | Alex Alonso | 105 | 115.7 | 2021 | |
| Jonathan Figueroa | 105 | 121.7 | 2018 | ||
| Glenn Woolard | 105 | 110.0 | 2014 | ||
| Joseph Dalton | 105 | 101.0 | 2008 | ||
| Nelson Cruz | 105 | 136.0 | 2007 | ||
| Ron Mahay | 105 | 88.3 | 2006 | ||
| Tim Worrell | 105 | 98.0 | 2004 | ||
| 34. | Robert Alicea | 104 | 113.7 | 2021 | |
| Miguel Castaņo | 104 | 117.7 | 2017 | ||
| Evan Meek | 104 | 101.3 | 2011 | ||
| Erasmo Ramirez | 104 | 89.0 | 2009 | ||
| Nelson Cruz | 104 | 132.0 | 2006 | ||
| Billy Wagner | 104 | 100.3 | 2005 | ||
| 40. | Evan Meek | 103 | 104.7 | 2016 | |
| Octavio Dotel | 103 | 96.0 | 2008 | ||
| Ron Mahay | 103 | 70.0 | 2007 | ||
| Justin Speier | 103 | 99.0 | 2005 | ||
| 44. | Jamie Vermilyea | 102 | 113.7 | 2014 | |
| Steven Addis | 102 | 109.0 | 2014 | ||
| Joe Nathan | 102 | 96.7 | 2008 | ||
| Javier Lopez | 102 | 87.7 | 2008 | ||
| Juan Cruz | 102 | 120.0 | 2007 | ||
| Francisco Rodriguez | 102 | 96.7 | 2007 | ||
| 50. | Cristian Marrero | 101 | 111.7 | 2022 | |
| Pelayo Lopez | 101 | 116.7 | 2020 | ||
| Everett Cortese | 101 | 131.3 | 2019 | ||
| Jose Perez | 101 | 128.3 | 2019 | ||
| Jonathan Figueroa | 101 | 92.0 | 2019 | ||
| Alex Alonso | 101 | 104.7 | 2018 | ||
| Angel Ortega | 101 | 125.7 | 2017 | ||
| Eddie Salvador | 101 | 106.0 | 2014 | ||
| Eric Gagne | 101 | 83.3 | 2014 | ||
| Kevin Rockey | 101 | 118.7 | 2012 | ||
| David Aardsma | 101 | 115.3 | 2012 | ||
| Chad Gaudin | 101 | 114.7 | 2012 | ||
| David Fuquay | 101 | 97.0 | 2010 | ||
| Tim Spooneybarger | 101 | 106.3 | 2008 | ||
| Pat Strange | 101 | 119.7 | 2005 | ||
| Brendan Donnelly | 101 | 95.7 | 2005 | ||
| Brad Lidge | 101 | 81.3 | 2005 | ||
| Brian Bowles | 101 | 113.7 | 2004 | ||
| 68. | Byron Lannon | 100 | 110.0 | 2022 | |
| Donald Walling | 100 | 108.0 | 2017 | ||
| Kamojirou Iemochi | 100 | 101.3 | 2017 | ||
| Douglas Cumbie | 100 | 96.0 | 2017 | ||
| Santiago Bocanegra | 100 | 95.7 | 2016 | ||
| Donald Walling | 100 | 91.7 | 2012 | ||
| Brandon Marron | 100 | 99.7 | 2008 | ||
| Luis Ayala | 100 | 97.3 | 2007 | ||
| Willis Roberts | 100 | 110.3 | 2005 | ||
| T.J. Tucker | 100 | 95.7 | 2005 | ||
| 78. | Alex Alonso | 99 | 112.0 | 2022 | |
| Stanley Middaugh | 99 | 104.3 | 2022 | ||
| Robert Clauson | 99 | 111.7 | 2018 | ||
| Tyler Clippard | 99 | 112.3 | 2016 | ||
| Ramon Ramirez | 99 | 105.7 | 2016 | ||
| Eddie Salvador | 99 | 125.3 | 2015 | ||
| Steven Addis | 99 | 119.3 | 2015 | ||
| Ryan Wagner | 99 | 87.0 | 2013 | ||
| Jose Santiago | 99 | 107.0 | 2009 | ||
| Joaquin Blanco | 99 | 101.3 | 2009 | ||
| Mark Corey | 99 | 129.3 | 2007 | ||
| Juan Rincon | 99 | 124.0 | 2007 | ||
| Brad Lidge | 99 | 89.7 | 2006 | ||
| Travis Driskill | 99 | 126.7 | 2005 | ||
| Mark Corey | 99 | 113.3 | 2004 | ||
| 93. | Jose Perez | 98 | 115.7 | 2022 | |
| Jay Peterson | 98 | 120.3 | 2021 | ||
| Angel Ortega | 98 | 122.7 | 2019 | ||
| Kelly Wise | 98 | 104.3 | 2017 | ||
| Eddie Salvador | 98 | 114.3 | 2016 | ||
| 98. | Dustin Conroy | 97 | 97.3 | 2022 | |
| Michael Kernan | 97 | 103.7 | 2021 | ||
| Alex Alonso | 97 | 117.3 | 2019 |
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