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| Single-Season Total Bases Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Total Bases | PA | Year | Career Leaderboard |
| 1. | Steven Schweigert | 440 | 671 | 2017 | |
| 2. | Steven Schweigert | 410 | 701 | 2016 | |
| 3. | Steven Schweigert | 408 | 689 | 2018 | |
| 4. | Johnny Hope | 404 | 682 | 2008 | |
| 5. | Saisaburou Keishi | 401 | 676 | 2017 | |
| 6. | Johnny Hope | 394 | 680 | 2012 | |
| Johnny Hope | 394 | 672 | 2011 | ||
| Vernon Wells | 394 | 671 | 2009 | ||
| 9. | Johnny Hope | 390 | 673 | 2013 | |
| 10. | Luis Gonzalez | 384 | 677 | 2004 | |
| 11. | Albert Pujols | 383 | 668 | 2010 | |
| 12. | Johnny Hope | 381 | 667 | 2009 | |
| 13. | Coy Holding | 379 | 674 | 2018 | |
| Jim Thome | 379 | 691 | 2004 | ||
| 15. | Curtis Pacheco | 377 | 643 | 2016 | |
| 16. | Johnny Hope | 376 | 660 | 2010 | |
| 17. | Johnny Hope | 374 | 674 | 2016 | |
| Albert Pujols | 374 | 664 | 2008 | ||
| 19. | Aubrey Huff | 372 | 690 | 2009 | |
| 20. | Curtis Pacheco | 371 | 671 | 2017 | |
| 21. | Juan Santiago | 370 | 618 | 2013 | |
| 22. | Steven Schweigert | 369 | 701 | 2019 | |
| 23. | Howard Pierre | 367 | 670 | 2022 | |
| Steven Schweigert | 367 | 705 | 2021 | ||
| 25. | Todd Helton | 365 | 668 | 2004 | |
| 26. | Russell Christensen | 364 | 642 | 2022 | |
| 27. | Michael Gaudette | 362 | 692 | 2022 | |
| Christopher Swarthout | 362 | 684 | 2015 | ||
| Vladimir Guerrero | 362 | 656 | 2004 | ||
| 30. | Christopher Swarthout | 361 | 682 | 2020 | |
| Jody Gerut | 361 | 661 | 2009 | ||
| 32. | Thomas Mattingly | 360 | 692 | 2009 | |
| 33. | Juan Santiago | 359 | 682 | 2017 | |
| Thomas Mattingly | 359 | 690 | 2015 | ||
| 35. | Albert Pujols | 358 | 655 | 2012 | |
| Todd Helton | 358 | 672 | 2007 | ||
| 37. | Johnny Hope | 357 | 698 | 2017 | |
| 38. | William Mikesell | 356 | 670 | 2021 | |
| Alex Cintron | 356 | 692 | 2009 | ||
| Manny Ramirez | 356 | 670 | 2005 | ||
| 41. | Shon Robbins | 355 | 695 | 2013 | |
| Vladimir Guerrero | 355 | 694 | 2006 | ||
| Vladimir Guerrero | 355 | 690 | 2005 | ||
| 44. | Herman Hofer | 354 | 678 | 2019 | |
| Saisaburou Keishi | 354 | 687 | 2015 | ||
| Juan Santiago | 354 | 649 | 2012 | ||
| Alex Rodriguez | 354 | 669 | 2005 | ||
| Todd Helton | 354 | 663 | 2005 | ||
| 49. | Simon Espinosa | 353 | 676 | 2019 | |
| Russell Christensen | 353 | 650 | 2019 | ||
| 51. | Michael Gaudette | 352 | 682 | 2021 | |
| 52. | Mark Leon | 351 | 671 | 2022 | |
| Cliff Floyd | 351 | 645 | 2006 | ||
| Miguel Cabrera | 351 | 640 | 2006 | ||
| 55. | Christopher Swarthout | 350 | 661 | 2014 | |
| 56. | Christopher Swarthout | 349 | 676 | 2018 | |
| Albert Pujols | 349 | 666 | 2009 | ||
| 58. | Christopher Swarthout | 348 | 691 | 2017 | |
| Johnny Hope | 348 | 649 | 2014 | ||
| Carlos Beltran | 348 | 697 | 2010 | ||
| Alfonso Soriano | 348 | 698 | 2005 | ||
| Albert Pujols | 348 | 664 | 2005 | ||
| 63. | Simon Espinosa | 347 | 680 | 2013 | |
| 64. | Luis Ayala Jr. | 346 | 655 | 2022 | |
| Saisaburou Keishi | 346 | 689 | 2016 | ||
| 66. | Thomas Mattingly | 345 | 667 | 2018 | |
| Miguel Cabrera | 345 | 657 | 2014 | ||
| 68. | Russell Christensen | 344 | 686 | 2020 | |
| Coy Holding | 344 | 715 | 2017 | ||
| 70. | Curtis Pacheco | 343 | 660 | 2022 | |
| Dalton Wicks | 343 | 711 | 2019 | ||
| Russell Christensen | 343 | 665 | 2017 | ||
| Miguel Cabrera | 343 | 658 | 2015 | ||
| Jody Gerut | 343 | 667 | 2007 | ||
| 75. | Magglio Ordonez | 342 | 692 | 2008 | |
| Eric Chavez | 342 | 675 | 2004 | ||
| 77. | Johnny Hope | 341 | 705 | 2021 | |
| Saisaburou Keishi | 341 | 639 | 2018 | ||
| Thomas Mattingly | 341 | 680 | 2010 | ||
| Alex Rodriguez | 341 | 674 | 2007 | ||
| Ben Broussard | 341 | 680 | 2005 | ||
| Jim Edmonds | 341 | 660 | 2005 | ||
| 83. | Vernon Wells | 340 | 680 | 2008 | |
| 84. | Thomas Mattingly | 339 | 660 | 2014 | |
| Saisaburou Keishi | 339 | 656 | 2012 | ||
| Andruw Jones | 339 | 634 | 2004 | ||
| 87. | Russell Christensen | 338 | 662 | 2021 | |
| Bobby Crosby | 338 | 697 | 2008 | ||
| 89. | Arnoldo Betancourt | 337 | 697 | 2022 | |
| David Murphy | 337 | 668 | 2012 | ||
| Corey Patterson | 337 | 674 | 2009 | ||
| Vladimir Guerrero | 337 | 687 | 2007 | ||
| Joe Crede | 337 | 648 | 2007 | ||
| Jeff Bagwell | 337 | 672 | 2004 | ||
| 95. | Rafael Barbosa | 336 | 620 | 2021 | |
| Curtis Pacheco | 336 | 663 | 2020 | ||
| Michael Gaudette | 336 | 664 | 2019 | ||
| 98. | Curtis Pacheco | 335 | 653 | 2015 | |
| Alfonso Soriano | 335 | 656 | 2004 | ||
| 100. | Thomas Mattingly | 334 | 669 | 2017 |
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