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| Single-Season RBIs Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | RBIs | PA | Year | Career Leaderboard |
| 1. | Vernon Wells | 164 | 671 | 2009 | |
| 2. | Steven Schweigert | 162 | 671 | 2017 | |
| 3. | Steven Schweigert | 161 | 701 | 2016 | |
| 4. | Coy Holding | 160 | 674 | 2018 | |
| 5. | Curtis Pacheco | 159 | 671 | 2017 | |
| 6. | Herman Salas | 157 | 689 | 2016 | |
| 7. | Curtis Pacheco | 156 | 653 | 2015 | |
| Shon Robbins | 156 | 694 | 2012 | ||
| 9. | Johnny Hope | 153 | 682 | 2008 | |
| 10. | Curtis Pacheco | 152 | 643 | 2016 | |
| 11. | Juan Santiago | 151 | 682 | 2017 | |
| 12. | Russell Christensen | 150 | 642 | 2022 | |
| Albert Pujols | 150 | 668 | 2010 | ||
| 14. | Aubrey Huff | 149 | 690 | 2009 | |
| 15. | Steven Schweigert | 147 | 705 | 2021 | |
| Saisaburou Keishi | 147 | 676 | 2017 | ||
| 17. | Luis Gonzalez | 146 | 677 | 2004 | |
| 18. | Miguel Cabrera | 144 | 658 | 2015 | |
| 19. | Steven Schweigert | 143 | 689 | 2018 | |
| Christopher Swarthout | 143 | 691 | 2017 | ||
| 21. | Michael Gaudette | 142 | 682 | 2021 | |
| Delmon Young | 142 | 677 | 2009 | ||
| Mike Lowell | 142 | 639 | 2004 | ||
| 24. | Thomas Mattingly | 141 | 669 | 2017 | |
| Vladimir Guerrero | 141 | 687 | 2007 | ||
| 26. | Simon Espinosa | 140 | 676 | 2019 | |
| Jody Gerut | 140 | 667 | 2007 | ||
| 28. | Johnny Hope | 139 | 680 | 2012 | |
| Jason Giambi | 139 | 600 | 2005 | ||
| 30. | Toshiichirou Toshitsugu | 138 | 671 | 2020 | |
| Magglio Ordonez | 138 | 674 | 2009 | ||
| Alex Rodriguez | 138 | 680 | 2008 | ||
| 33. | Johnny Hope | 137 | 698 | 2017 | |
| Johnny Hope | 137 | 673 | 2013 | ||
| Paul Konerko | 137 | 685 | 2012 | ||
| 36. | Mark Leon | 135 | 671 | 2022 | |
| Rafael Barbosa | 135 | 620 | 2021 | ||
| Daniel Corriveau | 135 | 684 | 2019 | ||
| Mark Leon | 135 | 685 | 2018 | ||
| Thomas Mattingly | 135 | 667 | 2018 | ||
| Johnny Hope | 135 | 672 | 2011 | ||
| 42. | Steven Schweigert | 134 | 701 | 2019 | |
| Carl Coil | 134 | 665 | 2019 | ||
| Russell Christensen | 134 | 650 | 2019 | ||
| Johnny Hope | 134 | 660 | 2010 | ||
| 46. | Michael Reisman | 133 | 676 | 2022 | |
| William Mikesell | 133 | 670 | 2021 | ||
| Juan Santiago | 133 | 618 | 2013 | ||
| Juan Santiago | 133 | 649 | 2012 | ||
| David Wright | 133 | 685 | 2006 | ||
| Manny Ramirez | 133 | 670 | 2005 | ||
| 52. | Michael Gaudette | 132 | 692 | 2022 | |
| Howard Pierre | 132 | 670 | 2022 | ||
| Saisaburou Keishi | 132 | 663 | 2019 | ||
| Christopher Bodie | 132 | 686 | 2017 | ||
| Magglio Ordonez | 132 | 692 | 2008 | ||
| John Buck | 132 | 621 | 2008 | ||
| 58. | Saisaburou Keishi | 131 | 689 | 2016 | |
| Jai Miller | 131 | 662 | 2016 | ||
| Vernon Wells | 131 | 680 | 2008 | ||
| Jim Edmonds | 131 | 660 | 2005 | ||
| 62. | Herman Hofer | 130 | 678 | 2019 | |
| Christopher Swarthout | 130 | 684 | 2015 | ||
| Shon Robbins | 130 | 695 | 2013 | ||
| Thomas Mattingly | 130 | 692 | 2009 | ||
| 66. | Arnoldo Betancourt | 129 | 697 | 2022 | |
| Saisaburou Keishi | 129 | 639 | 2018 | ||
| Simon Espinosa | 129 | 667 | 2017 | ||
| Billy Crunk | 129 | 691 | 2015 | ||
| Curtis Pacheco | 129 | 667 | 2013 | ||
| Saisaburou Keishi | 129 | 617 | 2013 | ||
| Austin Kearns | 129 | 692 | 2008 | ||
| Eric Chavez | 129 | 670 | 2008 | ||
| Mike Lowell | 129 | 628 | 2008 | ||
| Jim Edmonds | 129 | 641 | 2004 | ||
| 76. | Dan Kain | 128 | 704 | 2021 | |
| Saisaburou Keishi | 128 | 632 | 2020 | ||
| Johnny Hope | 128 | 689 | 2019 | ||
| Daniel Corriveau | 128 | 683 | 2017 | ||
| Bill Corchado | 128 | 675 | 2017 | ||
| Russell Christensen | 128 | 665 | 2017 | ||
| Christopher Swarthout | 128 | 661 | 2014 | ||
| Curtis Pacheco | 128 | 662 | 2012 | ||
| Jody Gerut | 128 | 663 | 2011 | ||
| Eric Chavez | 128 | 675 | 2004 | ||
| 86. | Steven Schweigert | 127 | 681 | 2020 | |
| Curtis Pacheco | 127 | 693 | 2019 | ||
| Johnny Hope | 127 | 674 | 2016 | ||
| Bill Corchado | 127 | 665 | 2015 | ||
| Curtis Pacheco | 127 | 669 | 2011 | ||
| Ben Broussard | 127 | 680 | 2005 | ||
| Lance Berkman | 127 | 669 | 2004 | ||
| Todd Helton | 127 | 668 | 2004 | ||
| 94. | Russell Christensen | 126 | 686 | 2020 | |
| Cristobal Rodriguez | 126 | 616 | 2019 | ||
| Simon Espinosa | 126 | 680 | 2013 | ||
| David Murphy | 126 | 668 | 2012 | ||
| David Wright | 126 | 680 | 2010 | ||
| Ben Broussard | 126 | 680 | 2010 | ||
| Vladimir Guerrero | 126 | 694 | 2006 |
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