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| Single-Season At-Bats Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | At-Bats | PA | Year | Career Leaderboard |
| 1. | Alvaro Baca | 713 | 768 | 2018 | |
| 2. | Michael Young | 695 | 746 | 2007 | |
| 3. | Alvaro Baca | 693 | 745 | 2019 | |
| 4. | Nomar Garciaparra | 688 | 743 | 2004 | |
| 5. | Rafael Furcal | 681 | 735 | 2009 | |
| 6. | Richard Keele | 680 | 751 | 2021 | |
| 7. | Alvaro Baca | 678 | 733 | 2017 | |
| 8. | Ichiro Suzuki | 672 | 720 | 2006 | |
| 9. | Hernan Leyba | 669 | 718 | 2022 | |
| Shin-Soo Choo | 669 | 729 | 2017 | ||
| 11. | Hanley Ramirez | 668 | 727 | 2015 | |
| Rafael Furcal | 668 | 728 | 2005 | ||
| 13. | Hector Made | 667 | 718 | 2018 | |
| David Zalewski | 667 | 750 | 2017 | ||
| Orlando Cabrera | 667 | 701 | 2006 | ||
| 16. | Hanley Ramirez | 665 | 723 | 2016 | |
| Shon Robbins | 665 | 732 | 2015 | ||
| Ichiro Suzuki | 665 | 724 | 2007 | ||
| 19. | Hanley Ramirez | 663 | 715 | 2020 | |
| Naofumi Doi | 663 | 740 | 2018 | ||
| 21. | Bobby Crosby | 662 | 727 | 2005 | |
| 22. | Hector Made | 661 | 703 | 2017 | |
| Hanley Ramirez | 661 | 715 | 2012 | ||
| Junior Spivey | 661 | 746 | 2005 | ||
| Scott Podsednik | 661 | 730 | 2005 | ||
| 26. | Aaron Herr | 660 | 703 | 2007 | |
| 27. | Scott Scruggs | 659 | 706 | 2018 | |
| Chad Tracy | 659 | 703 | 2006 | ||
| 29. | Steven Lafreniere | 658 | 713 | 2022 | |
| Hanley Ramirez | 658 | 714 | 2014 | ||
| 31. | Jose B. Reyes | 657 | 691 | 2021 | |
| Bobby McClendon | 657 | 695 | 2020 | ||
| Gabriel Pantoja | 657 | 730 | 2019 | ||
| Michael Young | 657 | 699 | 2006 | ||
| 35. | Jeremy Hermida | 656 | 706 | 2016 | |
| Shin-Soo Choo | 656 | 704 | 2010 | ||
| 37. | Tony Bill | 655 | 716 | 2022 | |
| 38. | Arnoldo Betancourt | 654 | 733 | 2021 | |
| Dalton Wicks | 654 | 711 | 2019 | ||
| Scott Scruggs | 654 | 704 | 2019 | ||
| Jose B. Reyes | 654 | 704 | 2013 | ||
| 42. | Max Brennan | 653 | 704 | 2019 | |
| Arnoldo Betancourt | 653 | 708 | 2018 | ||
| Jeremy Hermida | 653 | 716 | 2011 | ||
| Miguel Tejada | 653 | 710 | 2008 | ||
| 46. | Alvaro Baca | 652 | 692 | 2021 | |
| Hanley Ramirez | 652 | 717 | 2013 | ||
| Rocco Baldelli * | 652 | 713 | 2013 | ||
| Erick Aybar | 652 | 706 | 2013 | ||
| Chris Shelton | 652 | 702 | 2012 | ||
| Matt Holliday | 652 | 698 | 2009 | ||
| Jimmy Rollins | 652 | 720 | 2004 | ||
| 53. | Richard Keele | 651 | 720 | 2020 | |
| Dalton Wicks | 651 | 723 | 2012 | ||
| Jose B. Reyes | 651 | 696 | 2007 | ||
| Carl Crawford | 651 | 683 | 2006 | ||
| 57. | Victor Newman | 650 | 695 | 2016 | |
| Shannon Stewart | 650 | 723 | 2007 | ||
| 59. | Chris Seeger | 649 | 692 | 2021 | |
| Rickie Weeks | 649 | 715 | 2016 | ||
| 61. | Reid Courtright | 648 | 699 | 2022 | |
| Jose B. Reyes | 648 | 681 | 2008 | ||
| Rocco Baldelli * | 648 | 698 | 2006 | ||
| 64. | Ronald Gibson | 647 | 715 | 2021 | |
| Reggie Willits | 647 | 695 | 2013 | ||
| Ichiro Suzuki | 647 | 688 | 2011 | ||
| 67. | Reggie Willits | 646 | 686 | 2016 | |
| Orlando Hudson | 646 | 728 | 2011 | ||
| Hanley Ramirez | 646 | 702 | 2010 | ||
| Corey Patterson | 646 | 689 | 2007 | ||
| Jose B. Reyes | 646 | 697 | 2006 | ||
| 72. | Reggie Willits | 645 | 703 | 2012 | |
| Tommy Whiteman | 645 | 700 | 2009 | ||
| Scott Hairston | 645 | 702 | 2007 | ||
| Randy Winn | 645 | 715 | 2004 | ||
| 76. | Roland Bowes | 644 | 718 | 2017 | |
| Arnoldo Betancourt | 644 | 696 | 2017 | ||
| Tony Miller | 644 | 673 | 2012 | ||
| Adrian Beltre | 644 | 705 | 2010 | ||
| 80. | Oscar Gilcrease | 643 | 692 | 2022 | |
| Arnoldo Betancourt | 643 | 702 | 2020 | ||
| B.J. Upton | 643 | 680 | 2017 | ||
| Cristian Guzman | 643 | 695 | 2005 | ||
| 84. | Marquis Palomo | 642 | 720 | 2019 | |
| Richard Martines | 642 | 687 | 2019 | ||
| Rafael Furcal | 642 | 701 | 2012 | ||
| Rocco Baldelli * | 642 | 695 | 2007 | ||
| Rafael Furcal | 642 | 700 | 2004 | ||
| 89. | Victor Newman | 641 | 690 | 2018 | |
| Wayne Lydon | 641 | 674 | 2016 | ||
| David Zalewski | 641 | 718 | 2015 | ||
| 92. | William Archuleta | 640 | 679 | 2022 | |
| Raymond McLaurin | 640 | 714 | 2021 | ||
| Wayne Lydon | 640 | 681 | 2017 | ||
| James Shanks | 640 | 702 | 2015 | ||
| William Maldanado | 640 | 708 | 2013 | ||
| 97. | Max Brennan | 639 | 693 | 2021 | |
| Titus Lichtenstein | 639 | 695 | 2019 | ||
| James Shanks | 639 | 709 | 2014 | ||
| Edwin Encarnacion | 639 | 674 | 2011 |
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