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| Career Pitching HOF Standard Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Pitching HOF Standard | IP | ||
| 1. | Mark Prior * | 87 | 3710.9 | 2004-2019 | |
| 2. | J.D. Martin | 85 | 3544.9 | 2006-2021 | |
| 3. | Roger Heitman | 74 | 2877.6 | 2009-2021 | |
| Roy Halladay | 74 | 3306.0 | 2004-2016 | ||
| 5. | Brian Anderson | 67 | 2945.6 | 2011-2022 | |
| 6. | Freddie Cooley | 61 | 2306.3 | 2013-2022 | |
| 7. | Larry Strope | 57 | 3089.0 | 2005-2019 | |
| Joe Morgan Jr. | 57 | 3407.9 | 2006-2022 | ||
| 9. | Pedro Barranco | 56 | 3182.3 | 2006-2020 | |
| 10. | Lewis Washburn | 55 | 1612.7 | 2016-2022 | |
| 11. | Carlos Zambrano | 54 | 3401.6 | 2004-2020 | |
| 12. | Korey Mathison | 51 | 2127.0 | 2011-2022 | |
| Matt Capps | 51 | 2265.6 | 2009-2020 | ||
| Josh Beckett | 51 | 2517.3 | 2004-2016 | ||
| 15. | Thomas Gries | 50 | 2244.6 | 2011-2022 | |
| Jeremy Bonderman | 50 | 2060.9 | 2004-2013 | ||
| 17. | Augustine Stearn | 49 | 1806.0 | 2015-2022 | |
| Willian Larson | 49 | 2092.0 | 2013-2022 | ||
| 19. | Silvio Santacruz | 47 | 1604.0 | 2016-2022 | |
| Condel Ortiz | 47 | 2216.6 | 2013-2022 | ||
| Rick Ankiel | 47 | 2021.3 | 2005-2019 | ||
| 22. | Mark Mulder | 46 | 2946.3 | 2004-2016 | |
| 23. | Dontrelle Willis | 45 | 3084.6 | 2004-2018 | |
| Amadis Rodriguez | 45 | 1395.0 | 2017-2022 | ||
| Willie Leon | 45 | 1145.3 | 2018-2022 | ||
| Rick Hummel | 45 | 2173.6 | 2007-2017 | ||
| Felipe Granados | 45 | 1190.0 | 2018-2022 | ||
| Hosea Buendia | 45 | 1809.0 | 2014-2022 | ||
| Dennis Baley | 45 | 1340.0 | 2015-2022 | ||
| 30. | Josef Soliz | 43 | 2309.0 | 2011-2022 | |
| Henry Mosqueda | 43 | 1459.3 | 2016-2022 | ||
| 32. | Jose Silas | 42 | 2241.6 | 2013-2022 | |
| Nicholas Lehr | 42 | 2467.0 | 2010-2020 | ||
| 34. | Brandon Webb | 41 | 2583.3 | 2004-2017 | |
| 35. | Adam Muniz | 40 | 1916.0 | 2013-2022 | |
| 36. | Barry Zito | 39 | 2746.3 | 2004-2016 | |
| Bennie Hamblin | 39 | 1449.0 | 2015-2022 | ||
| 38. | Nick Younker | 38 | 2333.7 | 2011-2022 | |
| Joseph West | 38 | 1146.3 | 2007-2022 | ||
| Javier Vazquez | 38 | 2329.3 | 2004-2015 | ||
| Stanley Middaugh | 38 | 2040.9 | 2011-2022 | ||
| 42. | Johan Santana | 37 | 2403.3 | 2004-2017 | |
| Anthony Lezama | 37 | 2120.6 | 2011-2022 | ||
| 44. | John Moore | 36 | 2792.3 | 2008-2022 | |
| 45. | Roy Oswalt | 35 | 1151.3 | 2004-2008 | |
| Felix Hernandez | 35 | 2285.0 | 2009-2021 | ||
| Brett Evert | 35 | 2107.3 | 2005-2016 | ||
| 48. | C.C. Sabathia | 34 | 2636.3 | 2004-2017 | |
| Ubaldo Jimenez | 34 | 2375.3 | 2006-2019 | ||
| Mike Hinkley | 34 | 2746.6 | 2006-2019 | ||
| 51. | Glen Rakestraw | 33 | 2316.9 | 2008-2019 | |
| Odalis Perez | 33 | 2540.0 | 2004-2015 | ||
| Byung-Hyun Kim | 33 | 2480.3 | 2004-2016 | ||
| Tim Hudson | 33 | 2617.0 | 2004-2015 | ||
| 55. | Bruce Mule | 32 | 1688.0 | 2014-2022 | |
| 56. | Richard Menzies | 31 | 1257.6 | 2012-2018 | |
| Steven Maney | 31 | 1951.0 | 2011-2022 | ||
| 58. | Marvin Young | 30 | 1966.3 | 2014-2022 | |
| Daniel Scott | 30 | 2457.9 | 2009-2022 | ||
| Douglas Mondy | 30 | 1744.3 | 2012-2022 | ||
| Mark Michael | 30 | 1803.3 | 2007-2018 | ||
| Bobby Jenks | 30 | 2361.0 | 2007-2018 | ||
| Taylor Buchholz | 30 | 2366.9 | 2005-2018 | ||
| 64. | James Ramirez | 29 | 1961.6 | 2005-2015 | |
| Rafael Perez | 29 | 2500.0 | 2007-2020 | ||
| Darren Nigro | 29 | 1857.0 | 2009-2019 | ||
| 67. | Clint Nageotte | 28 | 1989.0 | 2006-2016 | |
| Dustin McGowan | 28 | 2429.9 | 2004-2019 | ||
| Pedro Martinez | 28 | 1236.6 | 2004-2010 | ||
| Zachery Hickman | 28 | 1086.0 | 2018-2022 | ||
| Aaron Cook | 28 | 2493.3 | 2004-2016 | ||
| Travis Blackley | 28 | 2348.3 | 2006-2019 | ||
| 73. | Brian Tiger | 27 | 1119.3 | 2017-2022 | |
| Zach Parker | 27 | 1963.0 | 2010-2020 | ||
| Matt Morris | 27 | 1281.0 | 2004-2010 | ||
| Jeff Francis | 27 | 2041.9 | 2004-2017 | ||
| Yorman Bazardo | 27 | 2285.6 | 2008-2020 | ||
| 78. | Danny Haren | 26 | 2616.0 | 2005-2018 | |
| 79. | Jamie Vermilyea | 25 | 1143.3 | 2006-2020 | |
| Matt Riley | 25 | 2101.6 | 2004-2018 | ||
| Gary Norton | 25 | 1216.6 | 2007-2022 | ||
| Bill Lazo | 25 | 1995.3 | 2012-2022 | ||
| Jake Dittler | 25 | 2088.0 | 2009-2018 | ||
| Lawrence Ballew | 25 | 1423.3 | 2015-2022 | ||
| Julian Abeyta | 25 | 2165.0 | 2012-2022 | ||
| 86. | Randy Wolf | 24 | 1389.0 | 2004-2011 | |
| Kyle Sleeth | 24 | 2154.3 | 2007-2018 | ||
| Francisco Rodriguez | 24 | 1363.3 | 2004-2022 | ||
| Greg Miller | 24 | 2668.3 | 2007-2022 | ||
| Rich Harden | 24 | 2225.3 | 2004-2017 | ||
| Everett Cortese | 24 | 1095.6 | 2011-2022 | ||
| 92. | Tim Stauffer | 23 | 1635.3 | 2005-2017 | |
| Amadeo Samaniego | 23 | 1189.0 | 2010-2018 | ||
| Jorge Ruiz | 23 | 1798.0 | 2012-2022 | ||
| Kevin Rockey | 23 | 1694.0 | 2010-2022 | ||
| Jake Peavy | 23 | 2431.3 | 2004-2017 | ||
| Clint Everts | 23 | 2309.3 | 2008-2020 | ||
| Ryan Drese | 23 | 1869.0 | 2004-2014 | ||
| Matt Clement | 23 | 1587.6 | 2004-2011 | ||
| 100. | Abraham Vidal | 22 | 1991.6 | 2010-2021 | |
| Joe Kennedy | 22 | 2415.0 | 2004-2015 | ||
| Pedro Galindo | 22 | 2003.3 | 2010-2022 | ||
| Jesse Foppert | 22 | 2477.6 | 2004-2016 | ||
| Adam Eaton | 22 | 1779.3 | 2004-2013 | ||
| Ronald Bay | 22 | 2057.6 | 2008-2021 | ||
| 106. | Grant Roberts | 21 | 1021.3 | 2004-2015 | |
| Kevin Millwood | 21 | 1514.6 | 2004-2011 | ||
| Gil Medina | 21 | 2090.6 | 2008-2022 | ||
| Seth McClung | 21 | 1801.0 | 2005-2016 | ||
| Trey Hodges | 21 | 1569.3 | 2004-2015 | ||
| Mark Buehrle | 21 | 1487.6 | 2004-2011 | ||
| Tony Armas | 21 | 1811.3 | 2004-2014 | ||
| Felton Allen | 21 | 2070.0 | 2012-2022 | ||
| 114. | Kerry Wood | 20 | 1539.0 | 2004-2012 | |
| Carlos Silva | 20 | 2585.6 | 2004-2017 | ||
| Tomo Ohka | 20 | 2240.0 | 2004-2014 | ||
| John Lackey | 20 | 1938.0 | 2004-2015 | ||
| Paul Hageman | 20 | 1386.6 | 2015-2022 | ||
| David Fuquay | 20 | 1036.3 | 2008-2022 | ||
| Berny Delgado | 20 | 1009.6 | 2010-2022 | ||
| Jack Cruys | 20 | 1197.3 | 2005-2018 | ||
| Bartolo Colon | 20 | 1345.0 | 2004-2010 | ||
| Joe Blanton | 20 | 1639.9 | 2007-2015 | ||
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